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Myosin light chain kinase
Inczefi O, Bacquie V, Olier-Pierre M, Rincel M, Ringot-Destrez B, Ellero-Simatos S, Eutamene H, Betoulieres C, Thomas J, Laine J, Gros L, Leveque M, Leonard R, Harkat C, Robbe-Masselot C, Roka R, Mercier-Bonin M, Theodorou V, Darnaudery M, Turner JR, Ferrier L. Targeted intestinal tight junction hyperpermeability alters the microbiome, behavior, and visceromotor responses. 2020. Cell Mol Gastroenterol Hepatol. 10, 206-208 e203. PMC7296230
SUMMARY
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PUBMED
Nalle SC, Zuo L, Ong M, Singh G, Worthylake AM, Choi W, Manresa MC, Southworth AP, Edelblum KL, Baker GJ, Joseph NE, Savage PA, Turner JR. Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability. 2019. J Clin Invest. 129, 902-914. PMC6355225
SUMMARY
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PUBMED
Graham WV, He W, Marchiando AM, Zha J, Singh G, Li HS, Biswas A, Ong M, Jiang ZH, Choi W, Zuccola H, Wang Y, Griffith J, Wu J, Rosenberg HJ, Wang Y, Snapper SB, Ostrov D, Meredith SC, Miller LW, Turner JR. Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis. 2019. Nat Med. 25, 690-700. PMC6461392
SUMMARY
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PUBMED
Edelblum KL, Sharon G, Singh G, Odenwald MA, Sailer A, Cao S, Ravens S, Thomsen I, El Bissati K, McLeod R, Dong C, Gurbuxani S, Prinz I, Mazmanian SK, Turner JR. The microbiome activates CD4 T-cell-mediated immunity to compensate for increased intestinal permeability. 2017. Cell Mol Gastroenterol Hepatol. 4, 285-297. PMC5540699
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PUBMED
Wu RL, Vazquez-Roque MI, Carlson P, Burton D, Grover M, Camilleri M, Turner JR. Gluten-induced symptoms in diarrhea-predominant irritable bowel syndrome are associated with increased myosin light chain kinase activity and claudin-15 expression. 2017. Lab Invest. 97, 14-23. PMC5215009
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PUBMED
Shashikanth N, Yeruva S, Ong M, Odenwald MA, Pavlyuk R, Turner JR. Epithelial organization: the gut and beyond. 2017. Compr Physiol. 7, 1497-1518
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PUBMED
Odenwald MA, Turner JR. The intestinal epithelial barrier: a therapeutic target?. 2017. Nat Rev Gastroenterol Hepatol. 14, 9-21. PMC5554468
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PUBMED
Choi W, Yeruva S, Turner JR. Contributions of intestinal epithelial barriers to health and disease. 2017. Exp Cell Res. 358, 71-77. PMC5958612
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PUBMED
Su L, Nalle SC, Shen L, Turner ES, Singh G, Breskin LA, Khramtsova EA, Khramtsova G, Tsai PY, Fu YX, Abraham C, Turner JR. TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. 2013. Gastroenterology. 145, 407-415. PMC3722284
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PUBMED
Buschmann MM, Shen L, Rajapakse H, Raleigh DR, Wang Y, Wang Y, Lingaraju A, Zha J, Abbott E, McAuley EM, Breskin LA, Wu L, Anderson K, Turner JR, Weber CR. Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux. 2013. Mol Biol Cell. 24, 3056-3068. PMC3784380
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PUBMED
Bradford EM, Turner ES, Turner JR. Understanding the epithelial barrier in IBD. 2012. Crohn's Disease and Ulcerative Colitis. 75-84
PDF
Cunningham KE, Turner JR. Myosin light chain kinase: pulling the strings of epithelial tight junction function. 2012. Ann N Y Acad Sci. 1258, 34-42. PMC3384706
PDF
PUBMED
Shen L, Weber CR, Raleigh DR, Yu D, Turner JR. Tight junction pore and leak pathways: a dynamic duo. 2011. Annual review of physiology. 73, 283-309. PMC4655434
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PUBMED
Graham WV, Magis AT, Bailey KM, Turner JR, Ostrov DA. Crystallization and preliminary X-ray analysis of the human long myosin light-chain kinase 1-specific domain IgCAM3. 2011. Acta Crystallogr Sect F Struct Biol Cryst Commun. 67, 221-223. PMC3034612
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PUBMED
Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JR. Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. 2010. J Biol Chem. 285, 12037-12046. PMC2852941
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PUBMED
Marchiando AM, Graham WV, Turner JR. Epithelial barriers in homeostasis and disease. 2010. Annu Rev Pathol. 5, 119-144
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PUBMED
Marchiando AM, Shen L, Graham WV, Weber CR, Schwarz BT, Austin JR, 2nd, Raleigh DR, Guan Y, Watson AJ, Montrose MH, Turner JR. Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. 2010. J Cell Biol. 189, 111-126. PMC2854371
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PUBMED
Yu D, Marchiando AM, Weber CR, Raleigh DR, Shen L, Turner JR, Wang Y. MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function. 2010. Proc Natl Acad Sci U S A. 107, 8237-8241. PMC2889526
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PUBMED
Turner JR. Intestinal mucosal barrier function in health and disease. 2009. Nat Rev Immunol. 9, 799-809
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PUBMED
Su L, Shen L, Clayburgh DR, Nalle SC, Sullivan EA, Meddings JB, Abraham C, Turner JR. Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. 2009. Gastroenterology. 136, 551-563. PMC2712351
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PUBMED
Shen L, Su L, Turner JR. Mechanisms and functional implications of intestinal barrier defects. 2009. Dig Dis. 27, 443-449. PMC2814011
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Schwarz BT, Wang F, Shen L, Clayburgh DR, Su L, Wang Y, Fu YX, Turner JR. LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. 2007. Gastroenterology. 132, 2383-2394. PMC2709832
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PUBMED
Graham WV, Wang F, Clayburgh DR, Cheng JX, Yoon B, Wang Y, Lin A, Turner JR. Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter. 2006. J Biol Chem. 281, 26205-26215
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Wang F, Schwarz BT, Graham WV, Wang Y, Su L, Clayburgh DR, Abraham C, Turner JR. IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. 2006. Gastroenterology. 131, 1153-1163. PMC1693969
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PUBMED
Clayburgh DR, Musch MW, Leitges M, Fu YX, Turner JR. Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. 2006. J Clin Invest. 116, 2682-2694. PMC1578628
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PUBMED
Turner JR. Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application. 2006. Am J Pathol. 169, 1901-1909. PMC1762492
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PUBMED
Shen L, Black ED, Witkowski ED, Lencer WI, Guerriero V, Schneeberger EE, Turner JR. Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. 2006. J Cell Sci. 119, 2095-2106
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PUBMED
Blair SA, Kane SV, Clayburgh DR, Turner JR. Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease. 2006. Lab Invest. 86, 191-201
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Wang F, Graham WV, Witkowski ED, Schwarz BT, Turner JR, Wang Y. Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. 2005v. Am J Pathol. 166, 409-419. PMC1237049
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PUBMED
Clayburgh DR, Barrett TA, Tang Y, Meddings JB, Van Eldik LJ, Watterson DM, Clarke LL, Mrsny RJ, Turner JR. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. 2005. J Clin Invest. 115, 2702-2715. PMC1224297
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PUBMED
Clayburgh DR, Shen L, Turner JR. A porous defense: the leaky epithelial barrier in intestinal disease. 2004. Lab Invest. 84, 282-291
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PUBMED
Clayburgh DR, Rosen S, Witkowski ED, Wang F, Blair S, Dudek S, Garcia JG, Alverdy JC, Turner JR. A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability. 2004 . J Biol Chem. 279, 55506-55513. PMC1237105
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PUBMED
Zolotarevsky Y, Hecht G, Koutsouris A, Gonzalez DE, Quan C, Tom J, Mrsny RJ, Turner JR. A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. 2002. Gastroenterology. 123, 163-172
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Turner JR, Madara JL. Physiological regulation of tight junction permeability by Na+-nutrient cotransport.. 2001. Tight Junctions. 333-347
Berglund JJ, Riegler M, Zolotarevsky Y, Wenzl E, Turner JR. Regulation of human jejunal transmucosal resistance and MLC phosphorylation by Na(+)-glucose cotransport. 2001. Am J Physiol Gastrointest Liver Physiol. 281, G1487-1493
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PUBMED
Turner JR. Show me the pathway! Regulation of paracellular permeability by Na(+)-glucose cotransport. 2000. Adv Drug Deliv Rev. 41, 265-281
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PUBMED
Turner JR, Rill BK, Carlson SL, Carnes D, Kerner R, Mrsny RJ, Madara JL. Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation. 1997. Am J Physiol. 273, C1378-1385
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PUBMED
Reviews
Zuo L, Kuo WT, Turner JR. Tight junctions as targets and effectors of mucosal immune homeostasis. 2020. Cell Mol Gastroenterol Hepatol. 10, 327-340. PMC7326733
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Herrmann JR, Turner JR. Beyond Ussing’s chambers: contemporary thoughts on integration of transepithelial transport. 2016. Am J Physiol Cell Physiol. 310, C423-431. PMC4796286
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Cell biology of tight junction structure & function
Graham WV, He W, Marchiando AM, Zha J, Singh G, Li HS, Biswas A, Ong M, Jiang ZH, Choi W, Zuccola H, Wang Y, Griffith J, Wu J, Rosenberg HJ, Wang Y, Snapper SB, Ostrov D, Meredith SC, Miller LW, Turner JR. Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis. 2019. Nat Med. 25, 690-700. PMC6461392
SUMMARY
PDF
PUBMED
Kuo WT, Shen L, Zuo L, Shashikanth N, Ong M, Wu L, Zha J, Edelblum KL, Wang Y, Wang Y, Nilsen SP, Turner JR. Inflammation-induced occludin downregulation limits epithelial apoptosis by suppressing caspase-3 expression. 2019. Gastroenterology. 157, 1323-1337. PMC6815722
SUMMARY
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PUBMED
Zha JM, Li HS, Lin Q, Kuo WT, Jiang ZH, Tsai PY, Ding N, Wu J, Xu SF, Wang YT, Pan J, Zhou XM, Chen K, Tao M, Odenwald MA, Tamura A, Tsukita S, Turner JR, He WQ. Interleukin 22 expands transit-amplifying cells while depleting Lgr5(+) stem cells via inhibition of wnt and notch signaling. 2019. Cell Mol Gastroenterol Hepatol. 7, 255-274. PMC6352747
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PUBMED
Odenwald MA, Choi W, Kuo WT, Singh G, Sailer A, Wang Y, Shen L, Fanning AS, Turner JR. The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo. 2018. J Biol Chem. 293, 17317-17335. PMC6231134
SUMMARY
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France M, Turner JR. The mucosal barrier at a glance. 2017. J Cell Sci. 130, 307-314. PMC5278669
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PUBMED
Shashikanth N, Yeruva S, Ong M, Odenwald MA, Pavlyuk R, Turner JR. Epithelial organization: the gut and beyond. 2017. Compr Physiol. 7, 1497-1518
PDF
PUBMED
Choi W, Yeruva S, Turner JR. Contributions of intestinal epithelial barriers to health and disease. 2017. Exp Cell Res. 358, 71-77. PMC5958612
PDF
PUBMED
Odenwald MA, Choi W, Buckley A, Shashikanth N, Joseph NE, Wang Y, Warren MH, Buschmann MM, Pavlyuk R, Hildebrand J, Margolis B, Fanning AS, Turner JR. ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture. 2017. J Cell Sci. 130, 243-259. PMC5394778
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PUBMED
Weber CR, Liang GH, Wang Y, Das S, Shen L, Yu AS, Nelson DJ, Turner JR. Claudin-2-dependent paracellular channels are dynamically gated. 2015. Elife. 4, e09906. PMC4755754
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PUBMED
Nalle SC, Turner JR. Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease. 2015. Mucosal Immunol. 8, 720-730
PDF
PUBMED
Buschmann MM, Shen L, Rajapakse H, Raleigh DR, Wang Y, Wang Y, Lingaraju A, Zha J, Abbott E, McAuley EM, Breskin LA, Wu L, Anderson K, Turner JR, Weber CR. Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux. 2013. Mol Biol Cell. 24, 3056-3068. PMC3784380
PDF
PUBMED
Bradford EM, Turner ES, Turner JR. Understanding the epithelial barrier in IBD. 2012. Crohn's Disease and Ulcerative Colitis. 75-84
PDF
Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I, Malissen B, Sperling AI, Turner JR. Dynamic migration of gammadelta intraepithelial lymphocytes requires occludin. 2012. Proc Natl Acad Sci U S A. 109, 7097-7102. PMC3345021
PDF
PUBMED
Cunningham KE, Turner JR. Myosin light chain kinase: pulling the strings of epithelial tight junction function. 2012. Ann N Y Acad Sci. 1258, 34-42. PMC3384706
PDF
PUBMED
Raleigh DR, Boe DM, Yu D, Weber CR, Marchiando AM, Bradford EM, Wang Y, Wu L, Schneeberger EE, Shen L, Turner JR. Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. 2011. J Cell Biol. 193, 565-582. PMC3087007
SUMMARY
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PUBMED
Marchiando AM, Shen L, Graham WV, Edelblum KL, Duckworth CA, Guan Y, Montrose MH, Turner JR, Watson AJ. The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. 2011. Gastroenterology. 140, 1208-1218 e1201-1202. PMC3066304
PDF
PUBMED
Shen L, Weber CR, Raleigh DR, Yu D, Turner JR. Tight junction pore and leak pathways: a dynamic duo. 2011. Annual review of physiology. 73, 283-309. PMC4655434
PDF
PUBMED
Marchiando AM, Shen L, Graham WV, Weber CR, Schwarz BT, Austin JR, 2nd, Raleigh DR, Guan Y, Watson AJ, Montrose MH, Turner JR. Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. 2010. J Cell Biol. 189, 111-126. PMC2854371
PDF
PUBMED
Marchiando AM, Graham WV, Turner JR. Epithelial barriers in homeostasis and disease. 2010. Annu Rev Pathol. 5, 119-144
PDF
PUBMED
Raleigh DR, Marchiando AM, Zhang Y, Shen L, Sasaki H, Wang Y, Long M, Turner JR. Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. 2010. Mol Biol Cell. 21, 1200-1213. PMC2847524
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PUBMED
Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JR. Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. 2010. J Biol Chem. 285, 12037-12046. PMC2852941
PDF
PUBMED
Yu D, Marchiando AM, Weber CR, Raleigh DR, Shen L, Turner JR, Wang Y. MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function. 2010. Proc Natl Acad Sci U S A. 107, 8237-8241. PMC2889526
PDF
PUBMED
Turner JR. Intestinal mucosal barrier function in health and disease. 2009. Nat Rev Immunol. 9, 799-809
PDF
PUBMED
Nalle SC, Turner JR. Menetrier’s disease therapy: rebooting mucosal signaling. 2009. Sci Transl Med. 1, 8ps10
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PUBMED
Su L, Shen L, Clayburgh DR, Nalle SC, Sullivan EA, Meddings JB, Abraham C, Turner JR. Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. 2009. Gastroenterology. 136, 551-563. PMC2712351
PDF
PUBMED
Graham WV, Marchiando AM, Shen L, Turner JR. No static at all. 2009. Ann N Y Acad Sci. 1165, 314-322. PMC2768559
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PUBMED
Weber CR, Nalle SC, Tretiakova M, Rubin DT, Turner JR. Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. 2008. Lab Invest. 88, 1110-1120. PMC2586671
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Shen L, Weber CR, Turner JR. The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. 2008. J Cell Biol. 181, 683-695. PMC2386107
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PUBMED
Schwarz BT, Wang F, Shen L, Clayburgh DR, Su L, Wang Y, Fu YX, Turner JR. LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. 2007. Gastroenterology. 132, 2383-2394. PMC2709832
PDF
PUBMED
Clayburgh DR, Musch MW, Leitges M, Fu YX, Turner JR. Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. 2006. J Clin Invest. 116, 2682-2694. PMC1578628
PDF
PUBMED
Wang F, Schwarz BT, Graham WV, Wang Y, Su L, Clayburgh DR, Abraham C, Turner JR. IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. 2006. Gastroenterology. 131, 1153-1163. PMC1693969
PDF
PUBMED
Turner JR. Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application. 2006. Am J Pathol. 169, 1901-1909. PMC1762492
PDF
PUBMED
Shen L, Black ED, Witkowski ED, Lencer WI, Guerriero V, Schneeberger EE, Turner JR. Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. 2006. J Cell Sci. 119, 2095-2106
PDF
PUBMED
Shen L, Turner JR. Role of epithelial cells in initiation and propagation of intestinal inflammation. Eliminating the static: tight junction dynamics exposed. 2006. Am J Physiol Gastrointest Liver Physiol. 290, G577-582
PDF
PUBMED
Wang F, Graham WV, Witkowski ED, Schwarz BT, Turner JR, Wang Y. Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. 2005v. Am J Pathol. 166, 409-419. PMC1237049
PDF
PUBMED
Shen L, Turner JR. Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis. 2005. Mol Biol Cell. 16, 3919-3936. PMC1196308
PDF
PUBMED
Clayburgh DR, Shen L, Turner JR. A porous defense: the leaky epithelial barrier in intestinal disease. 2004. Lab Invest. 84, 282-291
PDF
PUBMED
Clayburgh DR, Rosen S, Witkowski ED, Wang F, Blair S, Dudek S, Garcia JG, Alverdy JC, Turner JR. A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability. 2004 . J Biol Chem. 279, 55506-55513. PMC1237105
PDF
PUBMED
Zolotarevsky Y, Hecht G, Koutsouris A, Gonzalez DE, Quan C, Tom J, Mrsny RJ, Turner JR. A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. 2002. Gastroenterology. 123, 163-172
PDF
PUBMED
Berglund JJ, Riegler M, Zolotarevsky Y, Wenzl E, Turner JR. Regulation of human jejunal transmucosal resistance and MLC phosphorylation by Na(+)-glucose cotransport. 2001. Am J Physiol Gastrointest Liver Physiol. 281, G1487-1493
PDF
PUBMED
Tight junction permeability and disease pathogenesis
Raju P, Shashikanth N, Tsai PY, Pongkorpsakol P, Chanez-Paredes S, Steinhagen PR, Kuo WT, Singh G, Tsukita S, Turner JR. Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice. 2020. J Clin Invest. 130, 5197-5208. PMCID7524482
SUMMARY
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PUBMED
Inczefi O, Bacquie V, Olier-Pierre M, Rincel M, Ringot-Destrez B, Ellero-Simatos S, Eutamene H, Betoulieres C, Thomas J, Laine J, Gros L, Leveque M, Leonard R, Harkat C, Robbe-Masselot C, Roka R, Mercier-Bonin M, Theodorou V, Darnaudery M, Turner JR, Ferrier L. Targeted intestinal tight junction hyperpermeability alters the microbiome, behavior, and visceromotor responses. 2020. Cell Mol Gastroenterol Hepatol. 10, 206-208 e203. PMC7296230
SUMMARY
PDF
PUBMED
Ong M, Yeruva S, Sailer A, Nilsen SP, Turner JR. Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease. 2020. Lab Invest. 100, 483-490. PMC7047618
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PUBMED
Graham WV, He W, Marchiando AM, Zha J, Singh G, Li HS, Biswas A, Ong M, Jiang ZH, Choi W, Zuccola H, Wang Y, Griffith J, Wu J, Rosenberg HJ, Wang Y, Snapper SB, Ostrov D, Meredith SC, Miller LW, Turner JR. Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis. 2019. Nat Med. 25, 690-700. PMC6461392
SUMMARY
PDF
PUBMED
Kuo WT, Shen L, Zuo L, Shashikanth N, Ong M, Wu L, Zha J, Edelblum KL, Wang Y, Wang Y, Nilsen SP, Turner JR. Inflammation-induced occludin downregulation limits epithelial apoptosis by suppressing caspase-3 expression. 2019. Gastroenterology. 157, 1323-1337. PMC6815722
SUMMARY
PDF
PUBMED
Zha JM, Li HS, Lin Q, Kuo WT, Jiang ZH, Tsai PY, Ding N, Wu J, Xu SF, Wang YT, Pan J, Zhou XM, Chen K, Tao M, Odenwald MA, Tamura A, Tsukita S, Turner JR, He WQ. Interleukin 22 expands transit-amplifying cells while depleting Lgr5(+) stem cells via inhibition of wnt and notch signaling. 2019. Cell Mol Gastroenterol Hepatol. 7, 255-274. PMC6352747
PDF
PUBMED
Nalle SC, Zuo L, Ong M, Singh G, Worthylake AM, Choi W, Manresa MC, Southworth AP, Edelblum KL, Baker GJ, Joseph NE, Savage PA, Turner JR. Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability. 2019. J Clin Invest. 129, 902-914. PMC6355225
SUMMARY
PDF
PUBMED
Syed S, Yeruva S, Herrmann J, Sailer A, Sadiq K, Iqbal N, Kabir F, Ahmed K, Qureshi S, Moore SR, Turner J, Ali SA. Environmental enteropathy in undernourished Pakistani children: clinical and histomorphometric analyses. 2018. Am J Trop Med Hyg. 98, 1577-1584. PMC6086170
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PUBMED
Tsai PY, Zhang B, He WQ, Zha JM, Odenwald MA, Singh G, Tamura A, Shen L, Sailer A, Yeruva S, Kuo WT, Fu YX, Tsukita S, Turner JR. IL-22 upregulates epithelial claudin-2 to drive diarrhea and enteric pathogen clearance. 2017. Cell Host Microbe. 21, 671-681 e674. PMC5541253
SUMMARY
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PUBMED
Edelblum KL, Sharon G, Singh G, Odenwald MA, Sailer A, Cao S, Ravens S, Thomsen I, El Bissati K, McLeod R, Dong C, Gurbuxani S, Prinz I, Mazmanian SK, Turner JR. The microbiome activates CD4 T-cell-mediated immunity to compensate for increased intestinal permeability. 2017. Cell Mol Gastroenterol Hepatol. 4, 285-297. PMC5540699
PDF
PUBMED
Choi W, Yeruva S, Turner JR. Contributions of intestinal epithelial barriers to health and disease. 2017. Exp Cell Res. 358, 71-77. PMC5958612
PDF
PUBMED
Odenwald MA, Turner JR. The intestinal epithelial barrier: a therapeutic target?. 2017. Nat Rev Gastroenterol Hepatol. 14, 9-21. PMC5554468
PDF
PUBMED
Wu RL, Vazquez-Roque MI, Carlson P, Burton D, Grover M, Camilleri M, Turner JR. Gluten-induced symptoms in diarrhea-predominant irritable bowel syndrome are associated with increased myosin light chain kinase activity and claudin-15 expression. 2017. Lab Invest. 97, 14-23. PMC5215009
PDF
PUBMED
Edelblum KL, Turner JR. Epithelial cells: structure, transport, and barrier function. 2015. Mucosal Immunology. 4th Ed, 187-210
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Edelblum KL, Singh G, Lingaraju A, Turner JR. Gammadelta Intraepithelial lymphocyte migration limits transepithelial pathogen invasion and systemic disease in mice. 2015. Gastroenterology. 148, 1417-1426. PMC4685713
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PUBMED
Nalle SC, Turner JR. Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease. 2015. Mucosal Immunol. 8, 720-730
PDF
PUBMED
Nalle SC, Kwak HA, Edelblum KL, Joseph NE, Singh G, Khramtsova GF, Mortenson ED, Savage PA, Turner JR. Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease. 2014. Sci Transl Med. 6, 243ra287. PMC4161673
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PUBMED
Su L, Nalle SC, Shen L, Turner ES, Singh G, Breskin LA, Khramtsova EA, Khramtsova G, Tsai PY, Fu YX, Abraham C, Turner JR. TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. 2013. Gastroenterology. 145, 407-415. PMC3722284
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PUBMED
Odenwald MA, Turner JR. Intestinal permeability defects: is it time to treat?. 2013. Clin Gastroenterol Hepatol. 11, 1075-1083. PMC3758766
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PUBMED
Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I, Malissen B, Sperling AI, Turner JR. Dynamic migration of gammadelta intraepithelial lymphocytes requires occludin. 2012. Proc Natl Acad Sci U S A. 109, 7097-7102. PMC3345021
PDF
PUBMED
Bradford EM, Turner ES, Turner JR. Understanding the epithelial barrier in IBD. 2012. Crohn's Disease and Ulcerative Colitis. 75-84
PDF
Cunningham KE, Turner JR. Myosin light chain kinase: pulling the strings of epithelial tight junction function. 2012. Ann N Y Acad Sci. 1258, 34-42. PMC3384706
PDF
PUBMED
Marchiando AM, Shen L, Graham WV, Edelblum KL, Duckworth CA, Guan Y, Montrose MH, Turner JR, Watson AJ. The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. 2011. Gastroenterology. 140, 1208-1218 e1201-1202. PMC3066304
PDF
PUBMED
Raleigh DR, Boe DM, Yu D, Weber CR, Marchiando AM, Bradford EM, Wang Y, Wu L, Schneeberger EE, Shen L, Turner JR. Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. 2011. J Cell Biol. 193, 565-582. PMC3087007
SUMMARY
PDF
PUBMED
Marchiando AM, Graham WV, Turner JR. Epithelial barriers in homeostasis and disease. 2010. Annu Rev Pathol. 5, 119-144
PDF
PUBMED
Marchiando AM, Shen L, Graham WV, Weber CR, Schwarz BT, Austin JR, 2nd, Raleigh DR, Guan Y, Watson AJ, Montrose MH, Turner JR. Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. 2010. J Cell Biol. 189, 111-126. PMC2854371
PDF
PUBMED
Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JR. Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. 2010. J Biol Chem. 285, 12037-12046. PMC2852941
PDF
PUBMED
Graham WV, Marchiando AM, Shen L, Turner JR. No static at all. 2009. Ann N Y Acad Sci. 1165, 314-322. PMC2768559
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PUBMED
Shen L, Su L, Turner JR. Mechanisms and functional implications of intestinal barrier defects. 2009. Dig Dis. 27, 443-449. PMC2814011
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Nalle SC, Turner JR. Epithelium, tear down this wall!. 2009. Cell Host Microbe. 5, 1-2
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Su L, Shen L, Clayburgh DR, Nalle SC, Sullivan EA, Meddings JB, Abraham C, Turner JR. Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. 2009. Gastroenterology. 136, 551-563. PMC2712351
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Turner JR. Intestinal mucosal barrier function in health and disease. 2009. Nat Rev Immunol. 9, 799-809
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Weber CR, Nalle SC, Tretiakova M, Rubin DT, Turner JR. Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. 2008. Lab Invest. 88, 1110-1120. PMC2586671
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Weber CR, Turner JR. Inflammatory bowel disease: is it really just another break in the wall?. 2007. Gut. 56, 6-8. PMC1856658
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Schwarz BT, Wang F, Shen L, Clayburgh DR, Su L, Wang Y, Fu YX, Turner JR. LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. 2007. Gastroenterology. 132, 2383-2394. PMC2709832
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Clayburgh DR, Musch MW, Leitges M, Fu YX, Turner JR. Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. 2006. J Clin Invest. 116, 2682-2694. PMC1578628
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Wang F, Schwarz BT, Graham WV, Wang Y, Su L, Clayburgh DR, Abraham C, Turner JR. IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. 2006. Gastroenterology. 131, 1153-1163. PMC1693969
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Graham WV, Wang F, Clayburgh DR, Cheng JX, Yoon B, Wang Y, Lin A, Turner JR. Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter. 2006. J Biol Chem. 281, 26205-26215
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Turner JR. Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application. 2006. Am J Pathol. 169, 1901-1909. PMC1762492
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Shen L, Turner JR. Role of epithelial cells in initiation and propagation of intestinal inflammation. Eliminating the static: tight junction dynamics exposed. 2006. Am J Physiol Gastrointest Liver Physiol. 290, G577-582
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Blair SA, Kane SV, Clayburgh DR, Turner JR. Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease. 2006. Lab Invest. 86, 191-201
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Wang F, Graham WV, Witkowski ED, Schwarz BT, Turner JR, Wang Y. Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. 2005v. Am J Pathol. 166, 409-419. PMC1237049
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Clayburgh DR, Barrett TA, Tang Y, Meddings JB, Van Eldik LJ, Watterson DM, Clarke LL, Mrsny RJ, Turner JR. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. 2005. J Clin Invest. 115, 2702-2715. PMC1224297
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Shen L, Turner JR. Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis. 2005. Mol Biol Cell. 16, 3919-3936. PMC1196308
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Clayburgh DR, Shen L, Turner JR. A porous defense: the leaky epithelial barrier in intestinal disease. 2004. Lab Invest. 84, 282-291
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Zolotarevsky Y, Hecht G, Koutsouris A, Gonzalez DE, Quan C, Tom J, Mrsny RJ, Turner JR. A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. 2002. Gastroenterology. 123, 163-172
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Tight junction dysregulation: Mechanisms and druggability
Shashikanth N, France MM, Xiao R, Haest X, Rizzo HE, Yeste J, Reiner J, Turner JR. Tight junction channel regulation by interclaudin interference. 2022. Nat Commun. 13, 3780
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Zuo L, Kuo WT, Cao F, Chanez-Paredes SD, Zeve D, Mannam P, Jean-Francois L, Day A, Vallen Graham W, Sweat YY, Shashikanth N, Breault DT, Turner JR. Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn’s disease. 2022. Gut
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Graham WV, He W, Marchiando AM, Zha J, Singh G, Li HS, Biswas A, Ong M, Jiang ZH, Choi W, Zuccola H, Wang Y, Griffith J, Wu J, Rosenberg HJ, Wang Y, Snapper SB, Ostrov D, Meredith SC, Miller LW, Turner JR. Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis. 2019. Nat Med. 25, 690-700. PMC6461392
SUMMARY
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Odenwald MA, Turner JR. The intestinal epithelial barrier: a therapeutic target?. 2017. Nat Rev Gastroenterol Hepatol. 14, 9-21. PMC5554468
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Nalle SC, Turner JR. Menetrier’s disease therapy: rebooting mucosal signaling. 2009. Sci Transl Med. 1, 8ps10
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Tight junction physiology and pathophysiology
Raju P, Shashikanth N, Tsai PY, Pongkorpsakol P, Chanez-Paredes S, Steinhagen PR, Kuo WT, Singh G, Tsukita S, Turner JR. Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice. 2020. J Clin Invest. 130, 5197-5208. PMCID7524482
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Inczefi O, Bacquie V, Olier-Pierre M, Rincel M, Ringot-Destrez B, Ellero-Simatos S, Eutamene H, Betoulieres C, Thomas J, Laine J, Gros L, Leveque M, Leonard R, Harkat C, Robbe-Masselot C, Roka R, Mercier-Bonin M, Theodorou V, Darnaudery M, Turner JR, Ferrier L. Targeted intestinal tight junction hyperpermeability alters the microbiome, behavior, and visceromotor responses. 2020. Cell Mol Gastroenterol Hepatol. 10, 206-208 e203. PMC7296230
SUMMARY
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Ong M, Yeruva S, Sailer A, Nilsen SP, Turner JR. Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease. 2020. Lab Invest. 100, 483-490. PMC7047618
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Graham WV, He W, Marchiando AM, Zha J, Singh G, Li HS, Biswas A, Ong M, Jiang ZH, Choi W, Zuccola H, Wang Y, Griffith J, Wu J, Rosenberg HJ, Wang Y, Snapper SB, Ostrov D, Meredith SC, Miller LW, Turner JR. Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis. 2019. Nat Med. 25, 690-700. PMC6461392
SUMMARY
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Kuo WT, Shen L, Zuo L, Shashikanth N, Ong M, Wu L, Zha J, Edelblum KL, Wang Y, Wang Y, Nilsen SP, Turner JR. Inflammation-induced occludin downregulation limits epithelial apoptosis by suppressing caspase-3 expression. 2019. Gastroenterology. 157, 1323-1337. PMC6815722
SUMMARY
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Zha JM, Li HS, Lin Q, Kuo WT, Jiang ZH, Tsai PY, Ding N, Wu J, Xu SF, Wang YT, Pan J, Zhou XM, Chen K, Tao M, Odenwald MA, Tamura A, Tsukita S, Turner JR, He WQ. Interleukin 22 expands transit-amplifying cells while depleting Lgr5(+) stem cells via inhibition of wnt and notch signaling. 2019. Cell Mol Gastroenterol Hepatol. 7, 255-274. PMC6352747
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Nalle SC, Zuo L, Ong M, Singh G, Worthylake AM, Choi W, Manresa MC, Southworth AP, Edelblum KL, Baker GJ, Joseph NE, Savage PA, Turner JR. Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability. 2019. J Clin Invest. 129, 902-914. PMC6355225
SUMMARY
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Odenwald MA, Choi W, Kuo WT, Singh G, Sailer A, Wang Y, Shen L, Fanning AS, Turner JR. The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo. 2018. J Biol Chem. 293, 17317-17335. PMC6231134
SUMMARY
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Odenwald MA, Choi W, Buckley A, Shashikanth N, Joseph NE, Wang Y, Warren MH, Buschmann MM, Pavlyuk R, Hildebrand J, Margolis B, Fanning AS, Turner JR. ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture. 2017. J Cell Sci. 130, 243-259. PMC5394778
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France M, Turner JR. The mucosal barrier at a glance. 2017. J Cell Sci. 130, 307-314. PMC5278669
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Wu RL, Vazquez-Roque MI, Carlson P, Burton D, Grover M, Camilleri M, Turner JR. Gluten-induced symptoms in diarrhea-predominant irritable bowel syndrome are associated with increased myosin light chain kinase activity and claudin-15 expression. 2017. Lab Invest. 97, 14-23. PMC5215009
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Tsai PY, Zhang B, He WQ, Zha JM, Odenwald MA, Singh G, Tamura A, Shen L, Sailer A, Yeruva S, Kuo WT, Fu YX, Tsukita S, Turner JR. IL-22 upregulates epithelial claudin-2 to drive diarrhea and enteric pathogen clearance. 2017. Cell Host Microbe. 21, 671-681 e674. PMC5541253
SUMMARY
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Odenwald MA, Turner JR. The intestinal epithelial barrier: a therapeutic target?. 2017. Nat Rev Gastroenterol Hepatol. 14, 9-21. PMC5554468
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Choi W, Yeruva S, Turner JR. Contributions of intestinal epithelial barriers to health and disease. 2017. Exp Cell Res. 358, 71-77. PMC5958612
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Edelblum KL, Sharon G, Singh G, Odenwald MA, Sailer A, Cao S, Ravens S, Thomsen I, El Bissati K, McLeod R, Dong C, Gurbuxani S, Prinz I, Mazmanian SK, Turner JR. The microbiome activates CD4 T-cell-mediated immunity to compensate for increased intestinal permeability. 2017. Cell Mol Gastroenterol Hepatol. 4, 285-297. PMC5540699
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Shashikanth N, Yeruva S, Ong M, Odenwald MA, Pavlyuk R, Turner JR. Epithelial organization: the gut and beyond. 2017. Compr Physiol. 7, 1497-1518
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Weber CR, Liang GH, Wang Y, Das S, Shen L, Yu AS, Nelson DJ, Turner JR. Claudin-2-dependent paracellular channels are dynamically gated. 2015. Elife. 4, e09906. PMC4755754
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Edelblum KL, Turner JR. Epithelial cells: structure, transport, and barrier function. 2015. Mucosal Immunology. 4th Ed, 187-210
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Nalle SC, Turner JR. Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease. 2015. Mucosal Immunol. 8, 720-730
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Edelblum KL, Singh G, Lingaraju A, Turner JR. Gammadelta Intraepithelial lymphocyte migration limits transepithelial pathogen invasion and systemic disease in mice. 2015. Gastroenterology. 148, 1417-1426. PMC4685713
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Su L, Nalle SC, Shen L, Turner ES, Singh G, Breskin LA, Khramtsova EA, Khramtsova G, Tsai PY, Fu YX, Abraham C, Turner JR. TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. 2013. Gastroenterology. 145, 407-415. PMC3722284
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Buschmann MM, Shen L, Rajapakse H, Raleigh DR, Wang Y, Wang Y, Lingaraju A, Zha J, Abbott E, McAuley EM, Breskin LA, Wu L, Anderson K, Turner JR, Weber CR. Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux. 2013. Mol Biol Cell. 24, 3056-3068. PMC3784380
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Odenwald MA, Turner JR. Intestinal permeability defects: is it time to treat?. 2013. Clin Gastroenterol Hepatol. 11, 1075-1083. PMC3758766
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Bradford EM, Turner ES, Turner JR. Understanding the epithelial barrier in IBD. 2012. Crohn's Disease and Ulcerative Colitis. 75-84
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Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I, Malissen B, Sperling AI, Turner JR. Dynamic migration of gammadelta intraepithelial lymphocytes requires occludin. 2012. Proc Natl Acad Sci U S A. 109, 7097-7102. PMC3345021
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Marchiando AM, Shen L, Graham WV, Edelblum KL, Duckworth CA, Guan Y, Montrose MH, Turner JR, Watson AJ. The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. 2011. Gastroenterology. 140, 1208-1218 e1201-1202. PMC3066304
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Raleigh DR, Boe DM, Yu D, Weber CR, Marchiando AM, Bradford EM, Wang Y, Wu L, Schneeberger EE, Shen L, Turner JR. Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. 2011. J Cell Biol. 193, 565-582. PMC3087007
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Shen L, Weber CR, Raleigh DR, Yu D, Turner JR. Tight junction pore and leak pathways: a dynamic duo. 2011. Annual review of physiology. 73, 283-309. PMC4655434
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Marchiando AM, Graham WV, Turner JR. Epithelial barriers in homeostasis and disease. 2010. Annu Rev Pathol. 5, 119-144
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Marchiando AM, Shen L, Graham WV, Weber CR, Schwarz BT, Austin JR, 2nd, Raleigh DR, Guan Y, Watson AJ, Montrose MH, Turner JR. Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. 2010. J Cell Biol. 189, 111-126. PMC2854371
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Raleigh DR, Marchiando AM, Zhang Y, Shen L, Sasaki H, Wang Y, Long M, Turner JR. Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. 2010. Mol Biol Cell. 21, 1200-1213. PMC2847524
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Rajapakse HE, Gahlaut N, Mohandessi S, Yu D, Turner JR, Miller LW. Time-resolved luminescence resonance energy transfer imaging of protein-protein interactions in living cells. 2010. Proc Natl Acad Sci U S A. 107, 13582-13587. PMC2922258
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Yu D, Marchiando AM, Weber CR, Raleigh DR, Shen L, Turner JR, Wang Y. MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function. 2010. Proc Natl Acad Sci U S A. 107, 8237-8241. PMC2889526
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Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JR. Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. 2010. J Biol Chem. 285, 12037-12046. PMC2852941
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Graham WV, Marchiando AM, Shen L, Turner JR. No static at all. 2009. Ann N Y Acad Sci. 1165, 314-322. PMC2768559
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Shen L, Su L, Turner JR. Mechanisms and functional implications of intestinal barrier defects. 2009. Dig Dis. 27, 443-449. PMC2814011
PDF
PUBMED
Su L, Shen L, Clayburgh DR, Nalle SC, Sullivan EA, Meddings JB, Abraham C, Turner JR. Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. 2009. Gastroenterology. 136, 551-563. PMC2712351
PDF
PUBMED
Nalle SC, Turner JR. Epithelium, tear down this wall!. 2009. Cell Host Microbe. 5, 1-2
PDF
PUBMED
Turner JR. Intestinal mucosal barrier function in health and disease. 2009. Nat Rev Immunol. 9, 799-809
PDF
PUBMED
Weber CR, Nalle SC, Tretiakova M, Rubin DT, Turner JR. Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. 2008. Lab Invest. 88, 1110-1120. PMC2586671
PDF
PUBMED
Shen L, Weber CR, Turner JR. The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. 2008. J Cell Biol. 181, 683-695. PMC2386107
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PUBMED
Weber CR, Turner JR. Inflammatory bowel disease: is it really just another break in the wall?. 2007. Gut. 56, 6-8. PMC1856658
PDF
PUBMED
Turner JR. Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application. 2006. Am J Pathol. 169, 1901-1909. PMC1762492
PDF
PUBMED
Hu Z, Wang Y, Graham WV, Su L, Musch MW, Turner JR. MAPKAPK-2 is a critical signaling intermediate in NHE3 activation following Na+-glucose cotransporthu. 2006. J Biol Chem. 281, 24247-24253
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Clayburgh DR, Musch MW, Leitges M, Fu YX, Turner JR. Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. 2006. J Clin Invest. 116, 2682-2694. PMC1578628
PDF
PUBMED
Shen L, Turner JR. Role of epithelial cells in initiation and propagation of intestinal inflammation. Eliminating the static: tight junction dynamics exposed. 2006. Am J Physiol Gastrointest Liver Physiol. 290, G577-582
PDF
PUBMED
Shen L, Black ED, Witkowski ED, Lencer WI, Guerriero V, Schneeberger EE, Turner JR. Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. 2006. J Cell Sci. 119, 2095-2106
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Wang F, Schwarz BT, Graham WV, Wang Y, Su L, Clayburgh DR, Abraham C, Turner JR. IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. 2006. Gastroenterology. 131, 1153-1163. PMC1693969
PDF
PUBMED
Clayburgh DR, Barrett TA, Tang Y, Meddings JB, Van Eldik LJ, Watterson DM, Clarke LL, Mrsny RJ, Turner JR. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. 2005. J Clin Invest. 115, 2702-2715. PMC1224297
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Shiue H, Musch MW, Wang Y, Chang EB, Turner JR. Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation. 2005. J Biol Chem. 280, 1688-1695. PMC1237052
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Wang F, Graham WV, Witkowski ED, Schwarz BT, Turner JR, Wang Y. Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. 2005v. Am J Pathol. 166, 409-419. PMC1237049
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Zhao H, Shiue H, Palkon S, Wang Y, Cullinan P, Burkhardt JK, Musch MW, Chang EB, Turner JR. Ezrin regulates NHE3 translocation and activation after Na+-glucose cotransport. 2004. Proc Natl Acad Sci U S A. 101, 9485-9490. PMC439003
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Clayburgh DR, Rosen S, Witkowski ED, Wang F, Blair S, Dudek S, Garcia JG, Alverdy JC, Turner JR. A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability. 2004 . J Biol Chem. 279, 55506-55513. PMC1237105
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Zolotarevsky Y, Hecht G, Koutsouris A, Gonzalez DE, Quan C, Tom J, Mrsny RJ, Turner JR. A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. 2002. Gastroenterology. 123, 163-172
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Berglund JJ, Riegler M, Zolotarevsky Y, Wenzl E, Turner JR. Regulation of human jejunal transmucosal resistance and MLC phosphorylation by Na(+)-glucose cotransport. 2001. Am J Physiol Gastrointest Liver Physiol. 281, G1487-1493
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Turner JR, Black ED. NHE3-dependent cytoplasmic alkalinization is triggered by Na(+)-glucose cotransport in intestinal epithelia. 2001. Am J Physiol Cell Physiol. 281, C1533-1541
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Turner JR, Madara JL. Physiological regulation of tight junction permeability by Na+-nutrient cotransport.. 2001. Tight Junctions. 333-347
Turner JR, Black ED, Ward J, Tse CM, Uchwat FA, Alli HA, Donowitz M, Madara JL, Angle JM. Transepithelial resistance can be regulated by the intestinal brush border Na+-H+ exchanger NHE3. 2000. Am J Physiol Cell Physiol. 279, C1918-1924. C1918-1924
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Turner JR. Show me the pathway! Regulation of paracellular permeability by Na(+)-glucose cotransport. 2000. Adv Drug Deliv Rev. 41, 265-281
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Turner JR, Cohen DE, Mrsny RJ, Madara JL. Noninvasive in vivo analysis of human small intestinal paracellular absorption: regulation by Na+-glucose cotransport. 2000. Digestive diseases and sciences. 45, 2122-2126
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Turner JR, Angle JM, Black ED, Joyal JL, Sacks DB, Madara JL. Protein kinase C-dependent regulation of transepithelial resistance: the roles of myosin light chain and myosin light chain kinase. 1999. Am J Physiol. 277, C554-562
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Turner JR, Rill BK, Carlson SL, Carnes D, Kerner R, Mrsny RJ, Madara JL. Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation. 1997. Am J Physiol. 273, C1378-1385
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