• Postdoctoral positions available. - More Info
  • New paper in Nature Medicine defines novel means of preventing pathogenic tight junction dysregulation (April, 2019) - More Info
  • Congratulations Wei-Ting on being selected for an APS 2019 Research Recognition Award
  • New paper in CMGH shows that IL-22 has divergent effects on epithelial proliferation and pernmeability (March, 2019) - More Info
  • New paper in the Journal of Clinical Investigation reveals that MLCK-mediated intestinal permeability increases drive graft vs host disease (February, 2019) - More Info
  • New paper in the Journal of Biological Chemistry demonstrates critical contributions of ZO-1 to apical epithelial structure (December, 2018) - More Info
  • Congratulations Matt (on being selected for a JBC Author Profile)!!! - More Info

Our Research

LatA does not acutely disrupt ZO-1 distribution

Live imaging of MDCK monolayers stably expressing EGFP-ß-actin (green) and mRFP1-ZO-1 (red) collected while simultaneously measuring transepithelial electrical resistance. Addition of latrunculin A (latA), to inhibit ß-actin polymerization, causes transepithelial electrical resistance to fall within less than 5 min. This is not associated with any qualitative change in F-actin or ZO-1 distribution. The shape changes that occur at the end of the movie occur long after loss of transepithelial electrical resistance and are best interpreted as either secondary events or effects unrelated to tight junctions regulation. (Mol Biol Cell 2005;16:3919-36.)

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Our Goals 

Our interests are focused on how epithelia establish, maintain, and regulate barriers. This fundamental property is essential for survival of multicellular organisms and allows controlled interactions with the external environment and compartmentalization of distinct tissues. The structure that maintains these barriers and regulates flux between cells is the tight junction. The primary goal of our laboratory is to understand the biology of the tight junction.

We take a multidisciplinary approach that integrates cell and developmental biology, transport physiology, electrophysiology, structural biology, molecular biology, and mucosal immunology to define fundamentals of structure and function; understand mechanisms of regulation in vitro and in vivo models; determine the contributions of barrier dysfunction to gastrointestinal disease; understand the role of the epithelial barrier in regulating other mucosal processes, e.g. immune responses; and develop novel means to correct barrier function and restore health.

— Jerrold R. Turner MD, PhD

Jerrold R. Turner, MD, PhD
Professor of Pathology and Medicine

Brigham and


NRB 730
77 Avenue Louis Pasteur
Boston, MA 02115