CD3+ (green) T lymhocytes infiltrate the mucosa and E-cadherin (red) labeled epithelium when channels are active.
Albumin (pseudocolor) is normally retained within blood vessels (left). In GVHD (center and right), albumin leaks from vessels, but in mice lacking epithelial MLCK (right) albumin accumulates between epithelial cells (arrow).
Size- and charge-selective tight junction permeability increases promote resolution of infection.
Occludin and caspase-3 expression are coordinately reduced in Crohn's disease patient biopsies.
Neuronal activation in the thalamus of control mice (left) and mice with intestinal barrier loss (right).
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Congratulations Nitesh on being selected for an American Physiological Society Research Award (canceled due COVID)