The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22. [provided by RefSeq, Mar 2016]

Antibody charactierzation and validation (SLC9A3):

This commercial antibody from Abcam (ab101817*) was raised against “synthetic peptide from the C terminal region of Human Sodium/Hydrogen Exchanger 3 conjugated to an immunogenic carrier protein.” Antibodies are whole antiserum and has been tested in Western blot against the recombinant peptide used as an immunogen. In human formalin-fixed, paraffin, embedded tissue, localization on the apical surface of the villus of the small intestine (right, upper image) as well as in colon (right, lower image) was confirmed.