Christopher Weber : Turner Lab

Christopher Weber, M.D., Ph.D.

Postdoctoral Fellow (2007-2010), Instructor (2010-2012), Assistant Professor (2012-2016)

2007-2016

2007-2010 NIH F32, NIH LRP
2010-2012 NIH K08
2012-2016 NIH K08, NIH R03

Current Position: Associate Professor of Pathology, The University of Chicago

Publications

Yvellez OV, Rai V, Sossenheimer PH, Hart J, Turner JR, Weber C, El Jurdi K, Rubin DT. Cumulative histologic inflammation predicts colorectal neoplasia in ulcerative colitis: a validation study. 2021. Inflamm Bowel Dis. Jan 19, 203-206. 7813748
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Weber CR, Turner JR. Dynamic modeling of the tight junction pore pathway. 2017. Ann N Y Acad Sci. 1397, 209-218. PMC5488723
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Peters SA, Edogawa S, Sundt WJ, Dyer RB, Dalenberg DA, Mazzone A, Singh RJ, Moses N, Smyrk TC, Weber C, Linden DR, MacNaughton WK, Turner JR, Camilleri M, Katzka DA, Farrugia G, Grover M. Constipation-predominant irritable bowel syndrome females have normal colonic barrier and secretory function. 2017. Am J Gastroenterol. 112, 913-923. PMC5502210
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Weber CR, Liang GH, Wang Y, Das S, Shen L, Yu AS, Nelson DJ, Turner JR. Claudin-2-dependent paracellular channels are dynamically gated. 2015. Elife. 4, e09906. PMC4755754
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Bouyer PG, Tang X, Weber CR, Shen L, Turner JR, Matthews JB. Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1. 2013. Am J Physiol Gastrointest Liver Physiol. 304, G142-156. PMC3543646
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Buschmann MM, Shen L, Rajapakse H, Raleigh DR, Wang Y, Wang Y, Lingaraju A, Zha J, Abbott E, McAuley EM, Breskin LA, Wu L, Anderson K, Turner JR, Weber CR. Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux. 2013. Mol Biol Cell. 24, 3056-3068. PMC3784380
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Bergmann KR, Liu SX, Tian R, Kushnir A, Turner JR, Li HL, Chou PM, Weber CR, De Plaen IG. Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing enterocolitis. 2013. Am J Pathol. 182, 1595-1606. PMC3644725
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Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I, Malissen B, Sperling AI, Turner JR. Dynamic migration of gammadelta intraepithelial lymphocytes requires occludin. 2012. Proc Natl Acad Sci U S A. 109, 7097-7102. PMC3345021
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Lee G, Goretsky T, Managlia E, Dirisina R, Singh AP, Brown JB, May R, Yang GY, Ragheb JW, Evers BM, Weber CR, Turner JR, He XC, Katzman RB, Li L, Barrett TA. Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. 2012. Gastroenterology. 139, 869-881, 881 e861-869. PMC2930080
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Carey HV, Pike AC, Weber CR, Turner JR, Visser A, Beijer-Liefers SC, Bouma HR, Kroese FG. Impact of hibernation on gut microbiota and intestinal barrier function in ground squirrels. 2012. Living in a seasonal world. 281-291
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Shen L, Weber CR, Raleigh DR, Yu D, Turner JR. Tight junction pore and leak pathways: a dynamic duo. 2011. Annual review of physiology. 73, 283-309. PMC4655434
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Raleigh DR, Boe DM, Yu D, Weber CR, Marchiando AM, Bradford EM, Wang Y, Wu L, Schneeberger EE, Shen L, Turner JR. Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. 2011. J Cell Biol. 193, 565-582. PMC3087007
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Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JR. Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. 2010. J Biol Chem. 285, 12037-12046. PMC2852941
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Marchiando AM, Shen L, Graham WV, Weber CR, Schwarz BT, Austin JR, 2nd, Raleigh DR, Guan Y, Watson AJ, Montrose MH, Turner JR. Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. 2010. J Cell Biol. 189, 111-126. PMC2854371
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Yu D, Marchiando AM, Weber CR, Raleigh DR, Shen L, Turner JR, Wang Y. MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function. 2010. Proc Natl Acad Sci U S A. 107, 8237-8241. PMC2889526
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Mukherjee A, Morosky SA, Shen L, Weber CR, Turner JR, Kim KS, Wang T, Coyne CB. Retinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactions. 2009. J Biol Chem. 284, 6486-6494. PMC5405323
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Snoeks L, Weber CR, Wasland K, Turner JR, Vainder C, Qi W, Savkovic SD. Tumor suppressor FOXO3 participates in the regulation of intestinal inflammation. 2009. Lab Invest. 89, 1053-1062. PMC3048782
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Weber CR, Nalle SC, Tretiakova M, Rubin DT, Turner JR. Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. 2008. Lab Invest. 88, 1110-1120. PMC2586671
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Snoeks L, Weber CR, Turner JR, Bhattacharyya M, Wasland K, Savkovic SD. Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells. 2008. Infect Immun. 76, 4677-4685. PMC2546851
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Shen L, Weber CR, Turner JR. The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. 2008. J Cell Biol. 181, 683-695. PMC2386107
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Weber CR, Turner JR. Inflammatory bowel disease: is it really just another break in the wall?. 2007. Gut. 56, 6-8. PMC1856658
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Sun Q, Weber CR, Sohail A, Bernardo MM, Toth M, Zhao H, Turner JR, Fridman R. MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties. 2007. J Biol Chem. 282, 21998-22010. PMC1978545
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Lab Member

Christopher Weber, M.D., Ph.D.

Publications