Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. The CLDN4 gene is mutated in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple organ systems.

Antibody validation
This commercial monoclonal rabbit antibody was raised against a synthetic peptide derived from the C-terminal region of the human claudin-4. Our validation included staining of formalin-fixed, paraffin-embedded human duodenum, where the antibody decorated lateral membranes throughout the crypt-villus axis.