Wei-Ting Kuo : Turner Lab

Wei-Ting Kuo, Ph.D.

Postdoctoral Fellow

2016 – 2021
Current Position: Assistant Professor of Oral Biology, National Taiwan University

My research interests are particularly direct towards how epithelial immune receptors and tight junction proteins in regulation of gastrointestinal homeostasis on progression of bowel disease.

Education and Training

2005 B.S., National Taiwan Normal University

2008 M.S., National Taiwan University

2016 Ph.D., National Taiwan University, Department of Physiology (Linda C.H. Yu, Ph.D.)

2016– Post-doctoral research fellow, Department of Pathology (Jerrold Turner MD, Ph.D.), Brigham and Women’s Hospital, Boston, MA

Editorial Activities

2019– Reviewer, Cellular and Molecular Gastroenterology and Hepatology

Publications

Zuo L, Kuo WT, Cao F, Chanez-Paredes SD, Zeve D, Mannam P, Jean-Francois L, Day A, Vallen Graham W, Sweat YY, Shashikanth N, Breault DT, Turner JR. Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn’s disease. 2022. Gut
PDF PUBMED
Sweat YY, Abtahi S, Chanez-Paredes SD, Raju P, Zuo L, Shashikanth N , Kuo W-T, Turner JR. Modulation of Intestinal Disorders by Claudin-2 and Occludin Via Canonical and Noncanonical Mechanisms. 2022. Tight Junctions, 3rd Edition. González-Mariscal L, Editor . 85-107
PUBMED
Kuo WT, Odenwald MA, Turner JR, Zuo L. Tight junction proteins occludin and ZO-1 as regulators of epithelial proliferation and survival. 2022. Ann N Y Acad Sci
PDF PUBMED
Zuo L, Kuo WT, Cao F, Chanez-Paredes SD, Zeve D, Mannam P, Jean-Francois L, Day A, Vallen Graham W, Sweat YY, Shashikanth N, Breault DT, Turner JR. Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn’s disease. 2022. Gut
PDF PUBMED
Kuo WT, Zuo L, Odenwald MA, Madha S, Singh G, Gurniak CB, Abraham C, Turner JR. The Tight Junction Protein ZO-1 is Dispensable for Barrier Function but Critical for Effective Mucosal Repair. 2021. Gastroenterol. 161, 1924-1939. PMC8605999
PDF PUBMED
Chanez-Paredes SD, Abtahi S, Kuo WT, Turner JR. Differentiating Between Tight Junction-Dependent and Tight Junction-Independent Intestinal Barrier Loss In Vivo. 2021. Methods in Molecular Biology. 2367, 249-271. PMC8249353
PDF PUBMED
Raju P, Shashikanth N, Tsai PY, Pongkorpsakol P, Chanez-Paredes S, Steinhagen PR, Kuo WT, Singh G, Tsukita S, Turner JR. Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice. 2020. J Clin Invest. 130, 5197-5208. PMCID7524482
SUMMARY PDF PUBMED
Zuo L, Kuo WT, Turner JR. Tight junctions as targets and effectors of mucosal immune homeostasis. 2020. Cell Mol Gastroenterol Hepatol. 10, 327-340. PMC7326733
PDF PUBMED
Rutlin M, Rastelli D, Kuo WT, Estep JA, Louis A, Riccomagno MM, Turner JR, Rao M. The villin1 gene promoter drives cre recombinase expression in extraintestinal tissues. 2020. Cell Mol Gastroenterol Hepatol. 10, 864-867 e865. PMC7573669
PDF PUBMED
Cao F, Zhu L, Zhang J, Pongkorpsakol P, Kuo WT, Turner JR, Zhou Q, Wang Y, Chen F, Liu Y, Zuo L. Myosin light chain kinase is a potential target for hypopharyngeal cancer treatment. 2020. Biomed Pharmacother. 131, 110665. PMC8122670
PDF PUBMED
Zha JM, Li HS, Lin Q, Kuo WT, Jiang ZH, Tsai PY, Ding N, Wu J, Xu SF, Wang YT, Pan J, Zhou XM, Chen K, Tao M, Odenwald MA, Tamura A, Tsukita S, Turner JR, He WQ. Interleukin 22 expands transit-amplifying cells while depleting Lgr5(+) stem cells via inhibition of wnt and notch signaling. 2019. Cell Mol Gastroenterol Hepatol. 7, 255-274. PMC6352747
PDF PUBMED
Kuo WT, Shen L, Zuo L, Shashikanth N, Ong M, Wu L, Zha J, Edelblum KL, Wang Y, Wang Y, Nilsen SP, Turner JR. Inflammation-induced occludin downregulation limits epithelial apoptosis by suppressing caspase-3 expression. 2019. Gastroenterology. 157, 1323-1337. PMC6815722
SUMMARY PDF PUBMED
Odenwald MA, Choi W, Kuo WT, Singh G, Sailer A, Wang Y, Shen L, Fanning AS, Turner JR. The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo. 2018. J Biol Chem. 293, 17317-17335. PMC6231134
SUMMARY PDF PUBMED
Tsai PY, Zhang B, He WQ, Zha JM, Odenwald MA, Singh G, Tamura A, Shen L, Sailer A, Yeruva S, Kuo WT, Fu YX, Tsukita S, Turner JR. IL-22 upregulates epithelial claudin-2 to drive diarrhea and enteric pathogen clearance. 2017. Cell Host Microbe. 21, 671-681 e674. PMC5541253
SUMMARY PDF PUBMED
Wu LL, Peng WH, Kuo WT, Huang CY, Ni YH, Lu KS, Turner JR, Yu LC. Commensal bacterial endocytosis in epithelial cells is dependent on myosin light chain kinase-activated brush border fanning by interferon-gamma. 2014. Am J Pathol. 184, 2260-2274. PMC4188866
PDF PUBMED
Yu LC, Shih YA, Wu LL, Lin YD, Kuo WT, Peng WH, Lu KS, Wei SC, Turner JR, Ni YH. Enteric dysbiosis promotes antibiotic-resistant bacterial infection: systemic dissemination of resistant and commensal bacteria through epithelial transcytosis. 2014. Am J Physiol Gastrointest Liver Physiol. 307, G824-835. PMC4214854
PDF PUBMED
Yu LC, Huang CY, Kuo WT, Sayer H, Turner JR, Buret AG.. SGLT-1-mediated glucose uptake protects human intestinal epithelial cells against Giardia duodenalis-induced apoptosis. 2008. Int J Parasitol. 38, 923-934. PMC2693066
PDF PUBMED

Lab Member

Wei-Ting Kuo, Ph.D.

Education and Training

Editorial Activities

Publications