W Vallen Graham : Turner Lab

W Vallen Graham, Ph.D., M.S.

Ph.D. Student

2005-2010

Current Position: CSO, Thelium Therapeutics

Publications

Zuo L, Kuo WT, Cao F, Chanez-Paredes SD, Zeve D, Mannam P, Jean-Francois L, Day A, Vallen Graham W, Sweat YY, Shashikanth N, Breault DT, Turner JR. Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn’s disease. 2022. Gut
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Zuo L, Kuo WT, Cao F, Chanez-Paredes SD, Zeve D, Mannam P, Jean-Francois L, Day A, Vallen Graham W, Sweat YY, Shashikanth N, Breault DT, Turner JR. Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn’s disease. 2022. Gut
PDF PUBMED
He WQ, Wang J, Sheng JY, Zha JM, Graham WV, Turner JR. Contributions of myosin light chain kinase to regulation of epithelial paracellular permeability and mucosal homeostasis. 2020. Int J Mol Sci. 21. PMC7037368
PDF PUBMED
He WQ, Wang J, Sheng JY, Zha JM, Graham WV, Turner JR. Contributions of Myosin Light Chain Kinase to Regulation of Epithelial Paracellular Permeability and Mucosal Homeostasis. 2020. Int J Mol Sci. 21, 993. PMC7037368
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Graham WV, He W, Marchiando AM, Zha J, Singh G, Li HS, Biswas A, Ong M, Jiang ZH, Choi W, Zuccola H, Wang Y, Griffith J, Wu J, Rosenberg HJ, Wang Y, Snapper SB, Ostrov D, Meredith SC, Miller LW, Turner JR. Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis. 2019. Nat Med. 25, 690-700. PMC6461392
SUMMARY PDF PUBMED
Graham WV, Magis AT, Bailey KM, Turner JR, Ostrov DA. Crystallization and preliminary X-ray analysis of the human long myosin light-chain kinase 1-specific domain IgCAM3. 2011. Acta Crystallogr Sect F Struct Biol Cryst Commun. 67, 221-223. PMC3034612
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Marchiando AM, Shen L, Graham WV, Edelblum KL, Duckworth CA, Guan Y, Montrose MH, Turner JR, Watson AJ. The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. 2011. Gastroenterology. 140, 1208-1218 e1201-1202. PMC3066304
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Marchiando AM, Shen L, Graham WV, Weber CR, Schwarz BT, Austin JR, 2nd, Raleigh DR, Guan Y, Watson AJ, Montrose MH, Turner JR. Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. 2010. J Cell Biol. 189, 111-126. PMC2854371
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Marchiando AM, Graham WV, Turner JR. Epithelial barriers in homeostasis and disease. 2010. Annu Rev Pathol. 5, 119-144
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Graham WV, Marchiando AM, Shen L, Turner JR. No static at all. 2009. Ann N Y Acad Sci. 1165, 314-322. PMC2768559
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Graham WV, Wang F, Clayburgh DR, Cheng JX, Yoon B, Wang Y, Lin A, Turner JR. Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter. 2006. J Biol Chem. 281, 26205-26215
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Graham WV, Turner JR. Introduction to the host and bacterial pathogens. Overview of the epithelial cell. 2006. Bacterial-Epithelial Cell Cross-Talk: Molecular Mechanisms in Pathogenesis. 3-29
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Hu Z, Wang Y, Graham WV, Su L, Musch MW, Turner JR. MAPKAPK-2 is a critical signaling intermediate in NHE3 activation following Na+-glucose cotransporthu. 2006. J Biol Chem. 281, 24247-24253
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Wang F, Schwarz BT, Graham WV, Wang Y, Su L, Clayburgh DR, Abraham C, Turner JR. IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. 2006. Gastroenterology. 131, 1153-1163. PMC1693969
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Owens SE, Graham WV, Siccardi D, Turner JR, Mrsny RJ. A strategy to identify stable membrane-permeant peptide inhibitors of myosin light chain kinase. 2005. Pharm Res. 22, 703-709
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Russo JM, Florian P, Shen L, Graham WV, Tretiakova MS, Gitter AH, Mrsny RJ, Turner JR. Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure. 2005. Gastroenterology. 128, 987-1001. PMC1237051
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Wang F, Graham WV, Witkowski ED, Schwarz BT, Turner JR, Wang Y. Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. 2005v. Am J Pathol. 166, 409-419. PMC1237049
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