Gurminder Singh : Turner Lab

Gurminder Singh, M.S.

Senior Research Assistant

2012-2019

Current Position: Research Scientist. Abbvie.

Publications

Kuo WT, Zuo L, Odenwald MA, Madha S, Singh G, Gurniak CB, Abraham C, Turner JR. The Tight Junction Protein ZO-1 is Dispensable for Barrier Function but Critical for Effective Mucosal Repair. 2021. Gastroenterol. 161, 1924-1939. PMC8605999
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Raju P, Shashikanth N, Tsai PY, Pongkorpsakol P, Chanez-Paredes S, Steinhagen PR, Kuo WT, Singh G, Tsukita S, Turner JR. Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice. 2020. J Clin Invest. 130, 5197-5208. PMCID7524482
SUMMARY PDF PUBMED
Nalle SC, Zuo L, Ong M, Singh G, Worthylake AM, Choi W, Manresa MC, Southworth AP, Edelblum KL, Baker GJ, Joseph NE, Savage PA, Turner JR. Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability. 2019. J Clin Invest. 129, 902-914. PMC6355225
SUMMARY PDF PUBMED
Hugot J-P, Al Nabhani Z, Berrebi D, Martinez-Vinson C, Montcuquet N, Dietrich G, Singh G, Turner JR, Madre C, Roy M, Ogier-Denis E, Dussaillant M, Cerf-Bensussan N, Zouali H, Jung C, Daniel F, Barreau F. Nod2 protects 1 remote small intestinal sites in case of colonic inflammation. 2019. BioRxiv
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Graham WV, He W, Marchiando AM, Zha J, Singh G, Li HS, Biswas A, Ong M, Jiang ZH, Choi W, Zuccola H, Wang Y, Griffith J, Wu J, Rosenberg HJ, Wang Y, Snapper SB, Ostrov D, Meredith SC, Miller LW, Turner JR. Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis. 2019. Nat Med. 25, 690-700. PMC6461392
SUMMARY PDF PUBMED
Odenwald MA, Choi W, Kuo WT, Singh G, Sailer A, Wang Y, Shen L, Fanning AS, Turner JR. The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo. 2018. J Biol Chem. 293, 17317-17335. PMC6231134
SUMMARY PDF PUBMED
Tsai PY, Zhang B, He WQ, Zha JM, Odenwald MA, Singh G, Tamura A, Shen L, Sailer A, Yeruva S, Kuo WT, Fu YX, Tsukita S, Turner JR. IL-22 upregulates epithelial claudin-2 to drive diarrhea and enteric pathogen clearance. 2017. Cell Host Microbe. 21, 671-681 e674. PMC5541253
SUMMARY PDF PUBMED
Edelblum KL, Sharon G, Singh G, Odenwald MA, Sailer A, Cao S, Ravens S, Thomsen I, El Bissati K, McLeod R, Dong C, Gurbuxani S, Prinz I, Mazmanian SK, Turner JR. The microbiome activates CD4 T-cell-mediated immunity to compensate for increased intestinal permeability. 2017. Cell Mol Gastroenterol Hepatol. 4, 285-297. PMC5540699
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Luther J, Garber JJ, Khalili H, Dave M, Bale SS, Jindal R, Motola DL, Luther S, Bohr S, Jeoung SW, Deshpande V, Singh G, Turner JR, Yarmush ML, Chung RT, Patel SJ. Hepatic injury in nonalcoholic steatohepatitis contributes to altered intestinal permeability. 2015. Cell Mol Gastroenterol Hepatol. 1, 222-232. PMC4578658
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Edelblum KL, Singh G, Lingaraju A, Turner JR. Gammadelta Intraepithelial lymphocyte migration limits transepithelial pathogen invasion and systemic disease in mice. 2015. Gastroenterology. 148, 1417-1426. PMC4685713
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Nalle SC, Kwak HA, Edelblum KL, Joseph NE, Singh G, Khramtsova GF, Mortenson ED, Savage PA, Turner JR. Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease. 2014. Sci Transl Med. 6, 243ra287. PMC4161673
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Su L, Nalle SC, Shen L, Turner ES, Singh G, Breskin LA, Khramtsova EA, Khramtsova G, Tsai PY, Fu YX, Abraham C, Turner JR. TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. 2013. Gastroenterology. 145, 407-415. PMC3722284
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Brigham and
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