Wangsun Choi, Ph.D.
Associate Scientist (BWH) and Instructor (HMS)
Associate Scientist in Medicine, Brigham and Women's Hospital
Instructor in Medicine, Harvard Medical School
B.A., Genetic Engineering, 1997, Korea University, Seoul, South Korea
M.S., Life Science and Biotechnology, 1999, Korea University, Seoul, South Korea (Advisor: Dr. Kwangseog Ahn)
Ph.D., Biochemistry, 2008, University of Kentucky Lexington, Kentucky, USA (Advisor: Dr. Sidney W. Whiteheart)
Postdoctoral fellow, University of North Carolina at Chapel Hill, 2009-2016
The function of adhesion adaptor proteins in epithelial morphogenesis.
Advisor: Dr. Mark Peifer, Department of Biology
Postdoctoral fellow, University of Kentucky, 2008-2009
The Role ADP-ribosylation factor 6 (Arf6) in platelet activation.
Advisor: Dr. Sidney W. Whiteheart, Department of Molecular and Cellular Biochemistry
Choi W, Yeruva S, Turner JR. (2017) Contributions of intestinal epithelial barriers to health and disease. Exp Cell Res. doi: 10.1016/j.yexcr.2017.03.036. [Epub ahead of print]
Odenwald MA, Choi W, Buckley A, Shashikanth N, Joseph NE, Wang Y, Warren MH, Buschmann MM, Pavlyuk R, Hildebrand J, Margolis B, Fanning AS, and Turner JR. (2017) ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture. J Cell Sci. 130(1):243-259.
Choi W*, Acharya BR, Peyret G, Fardin MA, Mège RM, Ladoux B, Yap AS, Fanning AS, Peifer M.
Remodeling the zonula adherens in response to tension and the role of afadin in this response. J Cell Biol. (2016) 213(2):243-60.
(* first and co-corresponding author), Featured Article for Comment written by Jeff Hardin in JCB, F1000 Recommended Article
Choi W, Harris NJ, Sumigray KD. Peifer M.
Rap1 and Canoe/afadin are essential for establishment of apical-basal polarity in the Drosophila embryo. Mol Biol Cell. (2013) 24(7):945-63.
Choi W, Peifer M.
Cell biology. Arranging a cellular checkerboard. Science. (2011) 333(6046):1099-100.
Choi W, Jung KC, Nelson KS, Bhat MA, Beitel GJ, Peifer M, Fanning AS.
The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/Afadin and Enabled. Mol Biol Cell. (2011) 22(12):2010-30.
Sawyer JK, Choi W, Jung KC, He L, Harris NJ, Peifer M.
A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension. Mol Biol Cell. (2011) 22(14):2491-508.
Choi W, Karim ZA, Whiteheart SW.
Protein Expression in Platelets from Six Species that Differ in their Open Canalicular System. Platelets. (2010) 21(3):167-75.
Karim ZA, Choi W, Whiteheart SW.
Primary platelet signaling cascades and integrin-mediated signaling control ADP-ribosylation factor (Arf) 6-GTP levels during platelet activation and aggregation. J. Biol. Chem. (2008) 283(18):11995-2003.
Ren Q, Barber HK, Crawford GL, Karim ZA, Zhao C, Choi W, Wang CC, Hong W, Whiteheart SW.
Endobrevin/VAMP-8 is the primary v-SNARE for the platelet release reaction. Mol. Biol. Cell. (2007) 18(1):24-33.
Choi W, Karim ZA, Whiteheart SW.
Arf6 plays an early role in platelet activation by collagen and convulxin. Blood. (2006) 107(8):3145-3152
Schraw TD, Crawford GL, Ren Q, Choi W, Thurmond DC, Pessin J, Whiteheart SW.
Platelets from Munc18c heterozygous mice exhibit normal stimulus-induced release. Thromb. Haemost. (2004) 92(4):829-37.
Choi W, Eum SY, Lee YW, Hennig B, Robertson LW, Toborek M.
PCB 104-induced proinflammatory reactions in human vascular endothelial cells: relationship to cancer metastasis and atherogenesis. Toxicol. Sci. (2003) 75(1):47-56.